Genomic study reveals why children in remission from rheumatoid arthritis often experience recurrences
A new study published today in Arthritis Research & Therapy provides the first genomic characterization of remission in juvenile rheumatoid arthritis patients.
"It turns out that even though these children in remission appear to be perfectly normal and symptom-free, their immune systems are still perturbed," says James N. Jarvis, MD, clinical professor of pediatrics in the University at Buffalo School of Medicine and Biomedical Sciences and the study’s lead author.
The new study confirms preliminary research by Jarvis, suggesting that remission experienced by patients with [JRA] on medication is not a “return to normal” but is, instead, a distinct biological state. The study finds that this distinct biological state results from pro-inflammatory responses being counter-balanced by anti-inflammatory responses caused by gene expression changes that medication induces.
If you have any form of this disease, this is one study you needto read!